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KMID : 1140120120170040331
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Cancer Prevention Research
2012 Volume.17 No. 4 p.331 ~ p.337
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Tetraarsenic Hexoxide Demonstrates Anticancer Activities at Least in Part through Suppression of NF-κB-mediated Cellular Responses in Hep3B Human Hepatocellular Carcinoma Cells
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Abstract
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Tetraarsenic hexoxide (As4O6) has been used in Korean folk remedy for the treatment of cancer since the late 1980’s, and arsenic trioxide (As2O3) is currently used as a chemotherapeutic agent. However, evidence suggests that As4O6-induced cell death pathway was different from that of As2O3. Nuclear factor-κB (NF-κB) is a well-known transcription factor involved in cell proliferation, invasion and metastasis. Here, we investigated the effects of As4O6 on NF-κB activity and NF-κB-regulated gene expressions. As4O6 partially suppressed NF-κB activation induced by TNF-α, and inhibited cell proliferation induced by TNF. As4O6 also suppressed the downstream NF-κB-regulated proteins involved in caner antiapoptosis, proliferation, invasion, and metastasis. This study demonstrates that As4O6 have anticancer properties through suppression of NF-κB-mediated cellular responses.
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KEYWORD
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Tetraarsenic hexoxide, Nuclear factor-κB, Apoptosis, Hepatocellular carcinoma
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